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KMID : 0914820160160020085
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Journal of the Korean Gastric Cancer Association
2016 Volume.16 No. 2 p.85 ~ p.92
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Clinicopathological Significance of Elevated PIK3CA Expression in Gastric Cancer
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Jang Si-Hyong
Kim Kyung-Ju
Oh Mee-Hye
Lee Ji-Hye
Lee Hyun-Ju
Cho Hyun-Deuk
Han Sun-Wook
Son Myoung-Won
Lee Moon-Soo
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Abstract
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Purpose: PIK3CA is often mutated in a variety of malignancies, including colon, gastric, ovary, breast, and brain tumors. We investigated PIK3CA expression in gastric cancer and explored the relationships between the PIK3CA expression level and clinicopathological features as well as survival of the patients.
Materials and Methods: We examined PIK3CA expression in a tissue microarray of 178 gastric adenocarcinomas by immunohisto-chemistry and reviewed patients’ medical records.
Results: In our study, 112 of the 178 gastric cancer patients displayed positive PIK3CA expression. Overexpression of PIK3CA was cor-related with low grade differentiation (P=0.001), frequent lymphatic invasion (P=0.032), and high T stage (P=0.040). Patients with positive PIK3CA staining were more likely to display worse overall survival rate than those with negative PIK3CA staining, as determined by Kaplan-Meier survival analysis with log-rank test (P=0.047) and a univariate analysis using the Cox proportional hazard model (hazard ratio=1.832, P=0.051).
Conclusions: Elevated PIK3CA expression was significantly correlated with tumor invasiveness, tumor phenotypes, and poor patient survival.
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KEYWORD
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PIK3CA, Stomach neoplasms, Immunohistochemistry
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